Reid Hoffman is leaving Microsoft’s board to go ‘founder mode’ with startup Manus

Reid Hoffman is leaving Microsoft’s board after a profitable decade with the company. He plans to concentrate on his AI drug discovery startup, Manus, and return to a more hands-on founder role.

The move highlights how prominent tech investors and operators are shifting attention toward AI-driven biotech. Hoffman's departure also suggests experienced board members may increasingly leave established tech giants to pursue higher-risk, higher-upside AI ventures.

After a very profitable decade on Microsoft's board, Reid Hoffman is stepping down to focus on his AI drug discovery startup Manus.